By LAUREN HULL
Cattle Drive Casserole
8 steps
Prep:20minCook:30min
Cattle Drive Casserole is a robust and flavorful layered dish that blends the bold spirit of the Old West with a touch of Tex-Mex flair
Updated at: Sat, 18 Jul 2026 22:06:38 GMT
Nutrition balance score
Unbalanced
Glycemic Index
56
Moderate
Glycemic Load
25
High
Nutrition per serving
Calories753.4 kcal (38%)
Total Fat47.4 g (68%)
Carbs45.5 g (18%)
Sugars12 g (13%)
Protein34.7 g (69%)
Sodium1438.3 mg (72%)
Fiber2.6 g (9%)
% Daily Values based on a 2,000 calorie diet
Ingredients
6 servings
skillet
large
2mixing bowls
Medium
casserole dish
9 x 13′′
1.5 poundslean ground beef
1red bell pepper
seeded, chopped
1yellow onion
chopped
1 ouncetaco seasoning mix
2 ½ cupsBiscuit Mix
like Bisquick
1 cupwater
Cooking Spray
like
½ cupsour cream
½ cupmayonnaise
4 ouncesGreen Chiles
Diced, drained
1 ½ cupsCheddar Cheese
Fiesta Blend, shredded, divided
1 teaspoongarlic powder
½ cupSalsa
mild
Instructions
Step 1
Preheat the oven to 350℉.
Step 2
Heat a skillet over medium-high heat. Add the ground beef and break it apart with a spoon. Cook until no longer pink, stirring occasionally. Drain off any excess fat. (While the meat cooks, you can prepare the biscuit dough.)
Step 3
Prepare the Biscuit Dough: In a mixing bowl, combine the biscuit mix and water. Stir until well mixed, ideally using your hands for thorough blending. Spray a casserole dish with cooking spray and press the dough into the dish, spreading it out to the edges. Bake in the preheated oven for 5-8 minutes, or until the dough is set and lightly golden. Set aside, but keep the oven on.
Step 4
Add chopped onions and red bell pepper to the cooked ground beef. Stir and cook for about 4 minutes. Add taco seasoning and mix well. Remove from heat.
Step 5
Spread the cooked ground beef mixture evenly on top of the baked biscuit layer.
Step 6
In a medium bowl, combine sour cream, mayonnaise, drained green chiles, ¾ cup shredded cheese, and garlic powder. Mix until smooth. Carefully spread this mixture over the ground beef layer.
Step 7
Add small spoonfuls of salsa over the sour cream layer (no need to spread it out). Sprinkle the remaining shredded cheese evenly on top.
Step 8
Place the casserole back in the oven, uncovered, and bake for 30 minutes or until hot and bubbly.
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